Tamástslikt Cultural Institute tells the story of three American Indian Tribes, the Cayuse, Umatilla and Walla Walla, who for more than 10,000 years inhabited the Plateau region of the Pacific Northwest, U.S.A. They welcomed and assisted the Lewis and Clark Expedition in 1804-1806 and Clark documented the contacts in his journal. Some 40 years later, the Oregon Trail cut through the heart of their homelands. Tamástslikt brings the story alive with a 14,000 square foot exhibit space that incorporates artifacts, photography, video and interactive multi-media in world class exhibits. Its Museum Store sells American Indian art and crafts, as well as books and music and uniquely designed Pendleton Woolen Mills Indian blankets. It is located five minutes from Interstate 84, four miles east of Pendleton, Oregon.

Tamástslikt Cultural Institute is owned and operated by the Confederated Tribes of the Umatilla Indian Reservation.